Sam McMahon Trust » Working to find a cure

Working to find a Cure for Friedreich’s Ataxia

caroline — Mon, 17 Oct 2011 20:24:39 +0000

This year we are working with FARA Ireland to raise money so that we can find a cure for Friedreich’s Ataxia. They have fabulous Christmas Cards for sale. There are some many designs that we can’t decide which ones we like best.

Have a look on our shop page and see for yourself.

Repligen Investigates New Drug for the Treatment of Friedreich’s Ataxia

caroline — Thu, 13 May 2010 15:22:46 +0000

The Repligen Corporation announced today that it has lodged an application with the Food and Drug Administration (FDA) for a Phase 1 study of RG2833, a selective histone deacetylase 3 (HDAC-3) inhibitor. Pending FDA approval this will be this first step in the clinical development of RG2833 as a potential treatment for FA.

Repligen state that ‘preclinical studies in animal models and patients’ cells have shown that RG2833 crosses the blood brain barrier, activates the defective frataxin gene and increases the production of frataxin.’

To read the full press release you can go the FARA website here and go to News on the right hand side of the page.

A Way in Friedreich’s Ataxia

caroline — Fri, 12 Feb 2010 14:08:43 +0000

Check out this article in our Useful Information page, that was published in the January 2010 issue of Neurology Now. This is a publication of the American Academy of Neurologists. Although it is not a comprehensive review of all of the research that is going on in the world of FA, it does acknowledge the promising work that is being done by Dr Joel Gottesfeld in the field of HDAC inhibitors.